Journal: Bioactive Materials

Article Title: Ex vivo endothelialized cECM-enriched core–shell fibrous vascular graft promotes rapid regenerative remodeling in vivo

doi: 10.1016/j.bioactmat.2026.03.040

Figure Lengend Snippet: Schematic illustration depicting the fabrication of the core/shell PCL-cECM (C/S PE) vascular graft and the cell seeding process. A novel bioreactor was constructed to culture rBMSCs under dynamic conditions to promote endothelial differentiation. Subsequently, the pre-endothelialized C/S PE (EC) was implanted into the rat abdominal aorta for biological assessment.

Article Snippet: Cow pulmonary artery endothelial (CPAE, CCL-209, ATCC) endothelial cells were used for initial cytocompatibility screening to evaluate endothelial adhesion and material safety using a standardized mature endothelial model.

Techniques: Construct

Journal: Bioactive Materials

Article Title: Ex vivo endothelialized cECM-enriched core–shell fibrous vascular graft promotes rapid regenerative remodeling in vivo

doi: 10.1016/j.bioactmat.2026.03.040

Figure Lengend Snippet: in vitro biocompatibility evaluation . (A) MTT assay shows enhanced proliferation on C/S PE at day 7 (n = 5). (B) F-actin (green) and Hoechst (blue) staining reveal improved spreading and confluence compared with PCL and control. (C–D) Quantification of F-actin area (n = 3) and nuclei number (n = 3) confirm higher cytoskeletal organization and cell density. (E) Viability assay demonstrates increased survival on C/S PE at day 5. (F) Live/Dead staining shows predominantly viable cells with fewer dead cells (n = 5). (G) Schematic summary of C/S PE promoting endothelial proliferation, biocompatibility, and reduced cytotoxicity. Scale bars: 200 μm. Statistical significance was calculated by two-way ANOVA with Tukey's test. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. “N.S” means not significant.

Article Snippet: Cow pulmonary artery endothelial (CPAE, CCL-209, ATCC) endothelial cells were used for initial cytocompatibility screening to evaluate endothelial adhesion and material safety using a standardized mature endothelial model.

Techniques: In Vitro, MTT Assay, Staining, Control, Viability Assay

Journal: Bioactive Materials

Article Title: Ex vivo endothelialized cECM-enriched core–shell fibrous vascular graft promotes rapid regenerative remodeling in vivo

doi: 10.1016/j.bioactmat.2026.03.040

Figure Lengend Snippet: rBMSCs to endothelial differentiation and activation of different pathways . (A) Schematic representation of rBMSCs differentiated into ECs. (B) Immunofluorescent detection of (i) CD31, (ii) ICAM1, (iii) Flk1, and (iv) eNOS (scale bars: 200 μm). Quantitative analysis of circumferential coverage for (C) CD31, (D) ICAM1, (E) Flk1, and (F) eNOS (n = 4 sections). (G) Venn diagram displaying differentially expressed genes (DEGs) between rBMSCs and differentiated endothelial-like cells in C/S PE grafts analyzed via RNA sequencing. (H) Scatter plot visualizing the distribution of upregulated and downregulated DEGs. (I) Gene ontology (GO) analysis indicating enrichment of terms linked to endothelial proliferation, angiogenesis, and blood vessel development. (J–M) Heatmaps presenting clustered DEGs associated with cell differentiation (J), endothelial cell proliferation (K), angiogenesis (L), and blood vessel development (M). (N–O) Gene set enrichment analysis (GSEA) highlighting significant gene enrichment in angiogenesis and vascular remodeling pathways. (P) Bubble plot showing pathway enrichment and signaling activation, including VEGF, MAPK, PI3K-Akt, mTOR, HIF-1, Notch, TGF-β, and JAK-STAT pathways. (Q–R) Heatmaps illustrating the activation of Notch (Q) and VEGF (R) signaling pathway genes, supporting robust pathway engagement. (S) Circular plot showing marked upregulation of major endothelial genes (Vegfa, Nos3, Flt1, Kdr) compared to MSC-specific markers.

Article Snippet: Cow pulmonary artery endothelial (CPAE, CCL-209, ATCC) endothelial cells were used for initial cytocompatibility screening to evaluate endothelial adhesion and material safety using a standardized mature endothelial model.

Techniques: Activation Assay, RNA Sequencing, Cell Differentiation

Journal: Radiology Case Reports

Article Title: Use of overlapping Surpass Evolve Flow Diverters for the treatment of a ruptured P1 dissecting aneurysm in the context of bilateral carotid artery occlusion: A case report

doi: 10.1016/j.radcr.2026.04.058

Figure Lengend Snippet: EVT difficulty and double overlapping FD deployment for the ruptured aneurysms. (A) Coiling the AcomA aneurysm with LEO Baby stent assistance. Panel 1: DSA shows a small AcomA aneurysm (arrow) projecting upward. Panel 2: X-ray image (left) and roadmap image (right) show the LEO Baby stent was semi-deployed. The microcatheter (arrows) reached the aneurysm neck but could not enter the sac. Panel 3: X-ray image (left) and unsubtracted DSA (right) show the coil (arrows) was successfully pushed into the aneurysm with the stent acting as a backstop. (B) In-FD thrombosis.‌ ‌Panel 1:‌ DSA shows occlusion of the ICA due to in-FD thrombosis (left). X-ray image shows the semi-deployed FD (right). Panel 2: Following FD withdrawal, roadmap image shows ICA patency. ‌Panel 3:‌ X-ray shows the aneurysm coiled with Solitaire stent assistance (left). DSA shows the ICA patency (right). (C) Double overlapping FDs for a BBA.‌ Panel 1:‌ DSA shows a supraclinoid ICA BBA (arrow). Panel 2:‌ X-ray images show the first FD deployed to cover the BBA (left), the deployment of the second FD (middle), and the final configuration of the two overlapping FDs (right). Panel 3: DSA shows patency of the supraclinoid ICA and its branches, as well as an extracranial ICA aneurysm (arrow). (D) Double overlapping FDs for a VA dissection.‌ Panel 1:‌ CT (left) shows subarachnoid hemorrhage and hemorrhage in the fourth ventricle. CT angiography (right) shows a VA dissection (arrow). Panel 2:‌ The left image shows the double overlapping FDs with incomplete wall apposition (arrow). The right X-ray image shows improved wall apposition following mechanical massage using the microguidewire. Panel 3:‌ DSA shows patency of the VA and its branches. Abbreviations: AcomA, anterior communicating artery; BBA, blister-like aneurysm; CT, computed tomography; DSA, digital subtraction angiography; EVT, endovascular treatment; FD, flow diverter; ICA, internal carotid artery; PICA, posterior inferior cerebellar artery; VA, vertebral artery.

Article Snippet: An XT-27 microcatheter (Stryker Neurovascular, Fremont, CA, USA) was advanced into the left P1 segment and posterior communicating artery (PcomA) under the guidance of a Synchro 14 microguidewire (Stryker Neurovascular, Fremont, CA, USA).

Techniques: Dissection, Computed Tomography

Journal: Radiology Case Reports

Article Title: Use of overlapping Surpass Evolve Flow Diverters for the treatment of a ruptured P1 dissecting aneurysm in the context of bilateral carotid artery occlusion: A case report

doi: 10.1016/j.radcr.2026.04.058

Figure Lengend Snippet: Vessel perforation by a microguidewire during FD deployment. Panel 1: DSA (left) shows an anterior choroidal artery aneurysm (arrow). Roadmap image (middle) shows the FD being delivered across the aneurysm. Post-deployment DSA (right) reveals no abnormality. Panel 2: Xper CT (left) demonstrates SAH (circle), indicating vessel rupture. Three-dimensional DSA (middle) shows a rupture point (arrow) on the MCA upper trunk. Selective angiography (right) identifies the rupture point (arrow) and active contrast extravasation (asterisk). Panel 3: X-ray image (left) shows an inflated balloon (arrow) in the MCA upper trunk to occlude the rupture site. After 1 hour of occlusion, bleeding persisted. The MCA upper trunk was subsequently coiled through the balloon catheter (middle). DSA (right) confirms occlusion of the MCA upper trunk (arrow). Panel 4: Immediate postoperative Xper CT (left) shows increased SAH (circle). Postoperative day 5 CT (middle) reveals resorption of the SAH and a left frontal lobe infarction (circle). Postoperative day 6 magnetic resonance imaging (right) demonstrates acute left frontal lobe infarction. Abbreviations: CT, computed tomography; DSA, digital subtraction angiography; FD, flow diverter; L, left; MCA, middle cerebral artery; SAH, subarachnoid hemorrhage.

Article Snippet: An XT-27 microcatheter (Stryker Neurovascular, Fremont, CA, USA) was advanced into the left P1 segment and posterior communicating artery (PcomA) under the guidance of a Synchro 14 microguidewire (Stryker Neurovascular, Fremont, CA, USA).

Techniques: Magnetic Resonance Imaging, Computed Tomography

Journal: JNET Journal of Neuroendovascular Therapy

Article Title: Fogarty Catheter Removal of External Iliac Artery Thrombus Caused by Sheath-Related Thrombus Entrapment Following Mechanical Thrombectomy: A Case Report

doi: 10.5797/jnet.cr.2025-0157

Figure Lengend Snippet: Fogarty, Edwards Lifesciences, Irvine, CA, USA

Article Snippet: Thrombectomy was therefore performed using a Fogarty arterial embolectomy catheter (Edwards Lifesciences, Irvine, CA, USA).

Techniques: